Isolated elevation of aspartate aminotransferase (AST) in an asymptomatic patient due to macro-AST
نویسندگان
چکیده
منابع مشابه
Macro-AST in an asymptomatic young patient.
Elevated enzyme activities in plasma may sometimes be due to the presence of macroenzymes.1,2 Macroenzymes are high molecular mass complexes of plasma enzymes with immunoglobulins (IgG, IgA or IgM) or other plasma components with reduced plasma clearance and prolonged half life, resulting in elevated serum activities due to the “trapping” of the enzymes in serum.3 These results may thus be erro...
متن کاملDistribution of serum concentrations reported for macroenzyme aspartate aminotransferase (macro-AST)
BACKGROUND The presence of macroenzyme (M) is often the explanation of an isolated elevation of aspartate aminotransferase (AST). Where M is identified, it is reasonable for the clinician to ask where an individual patient's result fits in with known concentrations of M. In this context, we conducted a survey of literature to examine the distribution of reported serum concentrations of macro-AS...
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Elevated enzyme activities in plasma may at times be attributed to the presence of macro-enzymes. The macro-enzymes are often serum enzymes in complex with immunoglobulins, resulting in a greater molecular mass that cannot be filtered by renal glomeruli and are, hence, retained in the plasma. The aspartate aminotransferase (AST) can exist as a macro-enzyme, although it has been rarely reported....
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The levels of aspartate aminotransferase (AST/GOT) and alanine aminotransferase (ALT/GPT) in serum can help people diagnose body tissues especially the heart and the liver are injured or not. This article provides a comprehensive review of research activities that concentrate on AST/GOT and ALT/GPT detection techniques due to their clinical importance. The detection techniques include colorimet...
متن کاملPersistent increase in aspartate aminotransferase in an asymptomatic patient.
A 66-year-old woman without a preexisting history of liver disease presented with chest discomfort and dyspnea. Laboratory studies revealed an isolated increase in aspartate aminotransferase (AST) that prompted consultation with a hepatologist. The patient was a retired schoolteacher and took no medications. She affirmed alcohol use estimated at 2 oz of spirits daily. A physical examination rev...
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ژورنال
عنوان ژورنال: Journal of Clinical Laboratory Analysis
سال: 2018
ISSN: 0887-8013
DOI: 10.1002/jcla.22690